Acanthamoeba protease activity promotes allergic airway inflammation via protease-activated receptor 2.
Acanthamoeba is a free-living amoeba commonly present in the environment and often found in human airway cavities.Acanthamoeba possesses strong proteases that can elicit allergic airway inflammation.To our knowledge, the aeroallergenicity of Acanthamoeba has not been reported.We repeatedly inoculated mice with Acanthamoeba trophozoites or excretory